To create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human health and diagnosing, monitoring, and treating disease.
The goals of this seminar series are:
The HCA Biological Network Seminar Series is made possible through the generous support of the Chan Zuckerberg Initiative.
10:30-12:00 EST | 15:30-17:00 GMT
Arutha Kulasinghe
Uncoupling pathways involved in immunotherapy resistance: Insights from deep tissue profiling
Anna Pascual Reguant
Mapping the emergence and progression of colorectal cancer with whole transcriptome single molecule imaging
Ilya Korsunsky
Navigating the edges: a boundary-aware approach to tissue segmentation with Tessera
10:30-12:00 EDT | 15:30-17:00 BST
Reproduction Network - Roser Vento-Tormo
Mapping the human uterus in time and space
Reproduction Network - Ariella Shikanov
Cellular atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing
Reproduction Network - Cecilia Lindskog
A high-resolution spatio-temporal protein atlas of the human reproductive system
Reproduction Network - Santhilal Subhash
Ancestrally diverse single cell atlas of human gynecologic carcinosarcoma
10:30-12:00 EDT | 15:30-17:00 BST
Sanja Vickovic
Tissue and cellular spatiotemporal dynamics in colon aging
Fei Chen
Genomic tools for probing the rules of tissue organization
Leeat Keren
Unravelling structure in the tumor microenvironment using multiplexed imaging
Alan Mullen
Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution
10:30-12:00 EDT | 14:30-16:00 GMT
Samantha Morris
New genomic technologies to deconstruct and control cell identity
Eric Lubeck
Highly multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Nikolaus Rajewsky
Spatial Omics and Disease
Maria Brbic
Towards AI-driven Discoveries in Single-cell Genomics
10:30-12:00 EDT | 15:30-17:00 BST
Adipose Network - Anne Loft
Adipose tissue adaption to lifestyle and bariatric surgery-induced weight loss in obese patients
Lucas Massier
Comparability and integration of white adipose tissue single cell data
10:30-12:00 EDT | 15:30-17:00 BST
Lisa McGinnis (Genentech)
Employing new technologies to interrogate the biology of tumor-associated tertiary lymphoid structures
Alma Andersson (Genentech)
Employing new technologies to interrogate the biology of tumor-associated tertiary lymphoid structures
Sanja Vickovic (NYGC, Columbia University)
Spatial host-microbiome sequencing
Will Hwang (MGH)
Intercellular mechanisms of therapeutic resistance in pancreatic cancer identified by single-cell spatial transcriptomics
Rong Fan (Yale University)
Spatial Multi-Omics Sequencing via Deterministic Barcoding in Tissue
10:30-12:00 EST | 15:30-17:00 GMT
Malte Lücken
Atlas Integration updates
Evan Biederstedt
Cell Annotation Platform updates
10:30-12:00 EST | 15:30-17:00 GMT
Wei Kheng Teh
One place for all HCA data - The HCA Data Platform and how we can support the Bionetworks
Alexander Bernier
Practicing Ethics and Data Stewardship in Open Biorepositories
10:30-12:00 EDT | 15:30-17:00 BST
Kidney Network - Menna Clatworthy (University of Cambridge)
"A 4D Kidney Cell Atlas"
Kidney Network - Matthias Kretzler (University of Michigan)
"Defining the cellular landscape of kidney disease across network and continents"
10:30-12:00 EDT | 15:30-17:00 BST
Immune Network - Ramon Massoni (CNAG-CRG)
The periodic table of tonsillar cells
Daniel Rainbow (University of Cambridge)
Developing an Integrated Map of the Immune System in Humans Across Tissues and Ages
Ronald Germain (NIH/NIAID)
New 2D and 3D Imaging and Analytic Methods for Generation of Spatial Tissue Atlases
10:30-12:00 EDT | 15:30-17:00 BST
Reproduction Network - Pauliina Damdimopoulou (Karolinska Institute)
Characterization of human ovaries from birth to menopause
Alain Chédotal (Inserm)
Three-dimensional analysis of sexual differentiation in human embryos
Amander Clark (UCLA)
Development of the Ovary and Testis in Primates
10:30-12:00 EST | 15:30-17:00 GMT
Andrew Adey
Multimodal profiling
Pratiksha Thakore
Multimodal profiling
Sanja Vickovic
Spatial profiling
Eric Lubeck
Spatial profiling
Ron Germain
Imaging
10:30-12:00 EST | 15:30-17:00 GMT
Donna Pacicca
Establishing an Atlas of the Developing Skeleton: Single Cell Analysis of Healthy Pediatric Bone and Cartilage
Bruce Aronow
Interactively Exploring the Systems Biology of Cells, Tissues, and Biological Processes Using the ToppCell Datamine
Kathrin Bernt
Pediatric hematopoietic development - opportunities and challenges
Bartha Maria Knoppers
Pediatric Research Ethics: ‘Growing Up’
10:30-12:00 EST | 15:30-17:00 GMT
Eye Network - Joshua Sanes
Evolution of cell classes and types in the vertebrate retina
Pancreas Network - Klaus Kaestner
Multimodal analysis of the human pancreas in health and disease by the Human Pancreas Analysis Program (HPAP)
10:30-12:00 EDT | 15:30-17:00 BST
Nervous system Network - Ed Lein
Overview of progress in the Neuro network/BRAIN Initiative Cell Census Network
David Rowitch
High resolution spatial transcriptomics for brain development and disease
10:30-12:00 EDT | 15:30-17:00 BST
Oral & Craniofacial Network - Paul Sharpe
Data cherry picking and making connections: Telocytes and macrophages in periodontitis
Skin Network - Magnus Lynch
Decoding human skin in health and disease at single-cell resolution
10:30-12:00 EDT | 15:30-17:00 BST
Heart Network - Jonathan Seidman
Mapping the cellular complexity of the human heart
Musculoskeletal Network - Chris Buckley
The implications of the Human Cell atlas for Experimental Medicine studies in arthritis
10:30-12:00 EDT | 15:30-17:00 BST
Genetic diversity Network - Joseph Powell
Population-scale cellular genomics
Genetic diversity Network - Shyam Prabhakar
Genetic Diversity: New Cohort Studies on Immune Cells
Gut Network - Agne Antanaviciute
Spatiotemporal analysis of human intestinal development at single-cell resolution
10:30-12:15 EST | 15:30-17:15 GMT
Organoid Network - Hans Clevers
Adult stem cell-based organoids at single cell resolution
Development Network - Paola Arlotta
Development and disease of the human brain at single cell resolution
10:30-12:00 EST | 15:30-17:00 GMT
Adipose Network - Christian Wolfrum
A single cell approach to adipose plasticity and thermogenesis
Lung Network - Nick Banovich
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
10:30-12:00 EST | 15:30-17:00 GMT
Breast Network - Alecia-Jane Twigger
Unravelling the heterogeneity and function of human milk secretory cells using single-cell RNA-sequencing
Liver Network - Sonya MacParland
Mapping the human liver in health and disease with single-cell resolution